2. Signaling Pathways
  3. Anti-infection
    Metabolic Enzyme/Protease
  4. HIV Protease

HIV Protease

HIV Protease

Related Products

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HIV protease, a homodimeric aspartyl protease, is crucial for the viral life-cycle, cleaving proviral polyproteins, hence creating mature protein components that are required for the formation of an infectious virus. HIV protease cleaves newly synthesized polyproteins at the appropriate places to create the mature protein components of an infectious HIV virion. HIV protease is a critical drug target in designing anti-retroviral drugs to treat HIV/AIDS (acquired immune deficiency syndrome).

HIV-1 protease permits viral maturation by processing the Gag and Gag-Pro-Pol polyproteins. It recognizes and cleaves more than 12 different substrates leading to viral maturation. Similar to that of HIV-1, HIV-2 protease is also a homodimeric aspartyl enzyme that plays a vital role in the HIV life-cycle through processing of Gag and Gag-Pro-Pol precursor polyproteins leading to viral maturation.

HIV Protease Related Products (164):

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-116537
    A76889
    A76889 is an HIV-1 protease inhibitor.
    A76889
  • HY-17431R
    Fosamprenavir Calcium Salt (Standard)
    		Inhibitor
    Fosamprenavir Calcium Salt (GW433908G) (Standard) is the analytical standard of Fosamprenavir Calcium Salt (HY-17431R). This product is intended for research and analytical applications. Fosamprenavir Calcium Salt (GW433908G) is an orally active inhibitor targeting HIV-1 protease and is a prodrug of Amprenavir (HY-17430). Fosamprenavir Calcium Salt is hydrolyzed into Amprenavir (VX-478) by cell phosphatases in the intestinal epithelium. Amprenavir binds to the active site of HIV-1 protease, preventing the processing of viral gag and gag-pol polyprotein precursors, thereby inhibiting the formation of mature infectious virus particles and exerting anti-HIV-1 infection activity. Fosamprenavir Calcium Salt can be used for the study of human immunodeficiency virus (HIV-1) infection.
    Fosamprenavir Calcium Salt (Standard)
  • HY-100212
    JE-2147
    		Inhibitor
    JE-2147 (AG1776) is a potent dipeptide protease inhibitor with a Ki of 0.33 nM for HIV-1 protease. JE-2147 has effective activities against a wide spectrum of HIV-1, HIV-2, simian immunodeficiency virus, and various clinical HIV-1 strains in vitro.
    JE-2147
  • HY-90001R
    Ritonavir (Standard)
    		Inhibitor
    Ritonavir (Standard) is the analytical standard of Ritonavir. This product is intended for research and analytical applications. Ritonavir (ABT 538) is an inhibitor of HIV protease used to treat HIV infection and AIDS. Ritonavir is also a SARS-CoV 3CLpro inhibitor with an IC50 of 1.61 μM.
    Ritonavir (Standard)
  • HY-N2786
    8-Prenylluteone
    		Inhibitor
    8-Prenylluteone is a HIV-1 protease inhibitor, with an IC50 of 4 μM.
    8-Prenylluteone
  • HY-151197
    HIV protease-IN-1
    		Inhibitor
    HIV protease-IN-1 (compound 1·succinate) is a potent HIV protease non-peptidic inhibitor, can be used to research AIDS.
    HIV protease-IN-1
  • HY-123415
    PD 134922
    		Inhibitor
    PD 134922 is a potent renin and HIV-1 protease inhibitor with an IC50 of 15 nM against HIV-1 protease.
    PD 134922
  • HY-17003R
    Saquinavir mesylate (Standard)
    		Inhibitor
    Saquinavir mesylate (Standard) (Ro 31-8959/003 (Standard)) is the analytical standard of Saquinavir mesylate (HY-17003). This product is intended for research and analytical applications. Saquinavir (Ro 31-8959) mesylate is an orally active HIV protease inhibitor that can be used in the research of AIDS. Saquinavir mesylate also has anti-inflammatory activity and can induce apoptosis of human red blood cells.
    Saquinavir mesylate (Standard)
  • HY-155691
    HIV-1 protease-IN-12
    		Inhibitor
    HIV-1 protease-IN-12 (compound 35b) is a HIV-1 protease inhibitor with an IC50 of 0.51 nM. HIV-1 protease-IN-12 also inhibits drug-resistant variant.
    HIV-1 protease-IN-12
  • HY-17430S1
    Amprenavir-d4-1
    		Inhibitor
    Amprenavir-d4-1 is deuterium labeled Amprenavir. Amprenavir (VX-478) is a HIV protease inhibitor (Ki=0.6 nM) used to treat HIV infection. Amprenavir is also a SARS-CoV 3CLpro inhibitor with an IC50 of 1.09 μM.
    Amprenavir-d<sub>4</sub>-1
  • HY-159638
    Elunonavir
    Elunonavir (GS-1156) is a HIV protease inhibitor with a high barrier to resistance and excellent metabolic stability. Elunonavir is able to overcome rapid CYP-mediated metabolism, resulting in a significantly prolonged half-life and the potential to reduce dosing frequency without the need for pharmacokinetic enhancers.
    Elunonavir
  • HY-152200
    HIV-1 inhibitor-53
    		Inhibitor
    HIV-1 inhibitor-53 is a dual HIV-1 protease and reverse transcriptase inhibitor. HIV-1 inhibitor-53 inhibits HIV-1 protease (PR) and reverse transcriptase (RT) activity with IC50 values of 1.93 nM and 2.35 μM, respectively. HIV-1 inhibitor-53 can be used for the research of acquired immune deficiency syndrome (AIDS).
    HIV-1 inhibitor-53
  • HY-N10934
    Ganoderic acid GS-1
    		Inhibitor
    Ganoderic acid GS-1, a highly oxygenated lanostane-type triterpenoid, has anti-HIV-1 protease activities with an IC50 of 58 μM.
    Ganoderic acid GS-1
  • HY-17041R
    Darunavir Ethanolate (Standard)
    		Inhibitor
    Darunavir (Ethanolate) (Standard) is the analytical standard of Darunavir (Ethanolate). This product is intended for research and analytical applications. Darunavir ethanolate (TMC114 Ethanolate) is a potent HIV protease inhibitor used to treat and prevent HIV/AIDS. Darunavir has a Ki of 1 nM for wild type HIV-1 protease.
    Darunavir Ethanolate (Standard)
  • HY-P4019
    Ac-Ser-Gln-Asn-Tyr-Pro-Val-Val-NH2
    Ac-Ser-Gln-Asn-Tyr-Pro-Val-Val-NH2 is a substrato peptídico of HIV-1 protease. Ac-Ser-Gln-Asn-Tyr-Pro-Val-Val-NH2 acts as the variable substrate in a peptidolytic assay to quantify the inhibition of the protease.
    Ac-Ser-Gln-Asn-Tyr-Pro-Val-Val-NH2
  • HY-90001S2
    Ritonavir-d8
    		Inhibitor
    Ritonavir-d8 is deuterated labeled Ritonavir (HY-90001). Ritonavir (ABT 538) is an inhibitor of HIV protease used to treat HIV infection and AIDS. Ritonavir is also a SARS-CoV 3CLpro inhibitor with an IC50 of 1.61 μM.
    Ritonavir-d<sub>8</sub>
  • HY-149936
    HIV-1 protease-IN-8
    		Inhibitor
    HIV-1 protease-IN-8 (compound 34b) is a potent HIV-1 protease inhibitor with an IC50 value of 0.32 nM. HIV-1 protease-IN-8 displays IC50s of 0.29 μM and 1.90 μM for wild-type HIV-1 (HIV-1NL4-3) and drug-resistant variant (HIV-1MDR), respectively. HIV-1 protease-IN-8 displays robust antiviral activity against both wild-type HIV-1 and drug-resistant variant.
    HIV-1 protease-IN-8
  • HY-125712
    CGP 53820
    		Inhibitor
    CGP 53820 is an inhibitor for HIV protease, inhibits the complex of HIV-1 and HIV-2 protease with Ki of 9 and 53 nM for HIV-1 protease and HIV-2 protease. CGP 53820 can be used in AIDS research.
    CGP 53820
  • HY-15287S1
    Nelfinavir-d4
    		Inhibitor
    Nelfinavir-d4 is deuterated labeled Nelfinavir (HY-15287). Nelfinavir (AG-1341) is a potent and orally bioavailable HIV-1 protease inhibitor (Ki=2 nM) for HIV infection. Nelfinavir is a broad-spectrum, anticancer agent.
    Nelfinavir-d<sub>4</sub>
  • HY-147650
    HIV-1 protease-IN-5
    		Inhibitor
    HIV-1 protease-IN-5 (Compound 13c) is a HIV-1 protease inhibitor with an IC50 of 1.64 nM. HIV-1 protease-IN-5 shows remarkable activity against wild-type and DRV-resistant HIV-1 variants.
    HIV-1 protease-IN-5